Yes. Smartable works with Ledger, Trezor and Keystone. Your keys stay on the device, and every transaction is approved there — your phone cannot sign without it.
Ledger connects over Bluetooth or, on Android, by USB cable, for Ethereum and EVM networks, Solana and Bitcoin. Trezor connects by USB cable on Android, for the same networks. Keystone stays air-gapped and signs by QR code, for Ethereum and EVM networks.
On a Ledger, contract calls such as swaps may need blind signing turned on in the Ethereum app, where the device shows fewer details — review them in Smartable first.